I have wide feet and a high arch. This means that any pair of Vibram FiveFingers with something over the top of the foot is tight. So tight that I normally go up a size. The shoe fits width wise, but is always a bit long in the toes (stumble risk).
The good news is that the Vibram FiveFingers Bikila LS solves this problem. Vibram FiveFingers were made to fit like a glove, but us wide-footed folk had to settle with a not-so-precision-fit glove up until now. As soon as I put the Bikila LS on I thought, "So this is how they're supposed to fit!" Don't get the wrong idea, I still love my KSOs and Bikilas, but the Bikila LS fits perfectly.
I haven't had a chance to run in them, but I'll let you know how it goes as soon as I do.